National Cancer Institute
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2017 Cancer Systems Biology Consortium and Physical Sciences - Oncology Network Junior Investigator Meeting Poster Awardees

Ellen Langer, PhD.

Ellen Langer, PhD.
Title: Postdoctoral Researcher
Institution: Oregon Health & Science University

Research: Intratumoral heterogeneity resulting from cell-intrinsic and cell-extrinsic factors is a major cause of therapeutic resistance in breast cancer. Our current research is focused on understanding how targeted therapeutics affect differentiation state heterogeneity and plasticity in basal-like breast cancer, with the ultimate goal of designing combination therapies that effectively eliminate all tumor cell populations. We are also generating in vitro scaffold-free tumor tissue using a three-dimensional bioprinter system to assess the effects of stromal cells and cell-extrinsic factors on differentiation state heterogeneity and therapy-induced cancer cell state change.

Jae Hun Kim, PhD.

Jae Hun Kim, PhD
Title: Research Scientist
Institution: Harvard School of Public Health

Research: Cancer cells most often invade neighboring tissues not as individual entities but as collective groups, e.g. protruding sheets, clusters or strands. How such cells initially get motile and translocate to distant sites while maintaining cell-cell contacts? This research suggests that cell unjamming, in which cells undergo a transition from a solid-like phase to a liquid-like phase that is signified by cell shape changes, provides a gateway that allows tumor cells to move.