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2018 Research News


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Research Highlights

Recent publications from Drs. Odde, Largaespada, and Rosenfeld’s group

Recent publications from Drs. Zhu, Krogsgaard, and Thomas’s group

Recent publication from Dr. Discher’s group

  • Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes; published in Molecular Biology of the Cell

Recent publications from Dr. Ferrari’s group

  • The role of imaging in the clinical practice of radiation oncology for pancreatic cancer; published in Abdominal Radiology
  • Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma; published in AACR
  • Physics-based multiscale mass transport model in drug delivery and tumor microenvironment; published in bioRxiv

Recent publications from Dr. Fischbach & Dr. Cantley’s group

  • Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells—a novel mechanism for the obesity-breast cancer link; published in Nature
  • Toward a Genome Scale Sequence Specific Dynamic Model of Cell-Free Protein Synthesis in Escherichia coli; published in bioRxiv

Recent publications from Dr. Wirtz’s group

  • Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory; published in Science Direct

Recent publications from Dr. Groves & Weaver's group

  • Tissue Force Programs Cell Fate and Tumor Aggression; published in AACR
  • α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site; published in Molecular Biology of the Cell

Recent publications from Dr. White & Sarkaria’s group

  • Characterization of In Vivo Resistance to Osimertinib and JNJ-61186372, an EGFR/Met Bispecific Antibody, Reveals Unique and Consensus Mechanisms of Resistance; published in AACR

Recent publications from multiple PSOC’s & PSOPs

  • Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy; published in Nature