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Current Research News

 

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Research Highlights

Recent publications from Dr. Michor & Dr. Holland’s group

  • Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition; published in Cancer Discovery
  • Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution; published in Cancer Discovery
  • Mathematical Modeling Links Pregnancy-Associated Changes and Breast Cancer Risk; published in Cancer Discovery

Recent publications from Dr. Wirtz’s group

Recent publications from Dr. Ferrari’s group

  • Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity; published in Cancer Discovery
  • Evaluating the influence of mechanical stress on anticancer treatments through a multiphase porous media model; published in Science Direct

Recent publications from Drs. Odde, Largaespada, and Rosenfeld’s group

  • Shifting the optimal stiffness for cell migration; published in Nature Communications
  • Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix; published in Molecular Biology of the Cell
  • Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices; published in Science Direct
  • Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level; published in Science Direct

Recent publications from Drs. Gatenby, Gillies, and Anderson’s group

  • Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer; published in Science Direct

Recent publications from Dr. O’Halloran & Dr. Licht’s group

  • The damaging effect of passenger mutations on cancer progression; published in Cancer Discovery
  • Hi-C 2.0: An optimized Hi-C procedure for high-resolution genome-wide mapping of chromosome conformation; published in Science Direct
  • An orthogonal single-molecule experiment reveals multiple-attempt dynamics of type IA topoisomerases; published in Nature
  • Facilitated dissociation of transcription factors from single DNA binding sites; published in PNAS, Proceedings of the National Academy of Sciences
  • Review of interferometric spectroscopy of scattered light for the quantification of subdiffractional structure of biomaterials; published in Journal of Biomedical Optics

Recent publication from Dennis Discher’s group (Please change to say Dr. Discher’s group)

  • Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance; published in Nature
  • Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration; published in Science Direct
  • Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer; published in Annual Review of Biophysics

Recent publications from Dr. Groves & Weaver's group

  • Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate; published in Nature Communications

Recent publications from Dr. Fischbach & Dr. Cantley’s group

  • Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix; published in Molecular Biology of the Cell
  • Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index; published in American Association for Cancer Research

Recent publications from Dr. Rabadan & Dr. Iavorone’s group

  • Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development; published in Nature Biotechnology

Recent publication from Dennis Discher’s group

  • DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration; published in Current Biology
  • Mechanotransduction in cancer; published in Science Direct
  • Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients; published in APS Physics
  • SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors; published in Science Direct.

Recent publications from Dr. Rabadan & Dr. Iavorone’s group

  • Spatiotemporal genomic architecture informs precision oncology in glioblastoma; published in Nature Genetics

Recent publications from Dr. Fischbach & Dr. Cantley’s group

  • Bursting the Bubble – Nuclear Envelope Rupture as a Path to Genomic Instability; published in Science Direct

Recent publications from Dr. O’Halloran & Dr. Licht’s group

Recent publications from Dr. Michor & Dr. Holland’s group

  • Phase 1 study of twice weekly pulse dose and daily low-dose erlotinib as initial treatment for patients with EGFR-mutant lung cancers; published in Annals of Oncology

Recent publications from Dr. Ferrari’s group

  • Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination; published in Science Direct

Recent publications from Drs. Gatenby, Gillies, and Anderson’s group

  • Defining cancer subpopulations by adaptive strategies rather than molecular properties provides novel insights into intratumoral evolution; published in Cancer Research

Recent publications from Drs. Odde, Largaespada, and Rosenfeld’s group

  • Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration; published in Nature Communications

Recent publications from Dr. Kamm’s group

  • On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics; published in Nature Protocols
  • Interplay of Platelet Contractility and Elasticity of Fibrin/Erythrocytes in Blood Clot Retraction; published in Science Direct
  • Brillouin flow cytometry for label-free mechanical phenotyping of the nucleus; published in Lab on a Chip

Recent publications from Dr. Groves & Weaver’s group

  • Force-dependent breaching of the basement membrane; published in Science Direct

Recent publications from multiple PSOC’s & PSOPs