Recent publication from Dennis Discher’s group
DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration; published in Current Biology
Moffitt researchers predict melanoma responses through mathematical modeling
A study led by Alexander "Sandy" Anderson, Ph.D., a PI of the Moffitt Cancer Center PS-OC and Chair of the Integrated Mathematical Oncology (IMO) department at Moffitt Cancer Center, and Eunjung Kim, Ph.D., an applied research scientist, shows how mathematical modeling can accurately predict patient responses to cancer drugs in a virtual clinical trial. By using a range of mathematical modeling approaches targeted at specific types of cancer, these researchers are aiding in the development and testing of new treatment strategies, as well as facilitating a deeper understanding of why they fail. This study was recently published in the November issue of the European Journal of Cancer.
- Evolutionary Principles Used to Prolong Tumor Control
A study led by Robert Gatenby and Robert Gillies of the H. Lee Moffitt Cancer Center and Research Institute
- Activation of proto-oncogenes by disruption of chromosome neighborhoods
A study by Dr. Job Dekker, co-investigator of the Northwestern University PS-OC was recently published in Science Magazine. The research article discusses the activation of proto-oncogenes by disruption of chromosome neighborhoods. These findings strongly support disruption of chromatin structure as causally linked to tumorigenesis, and suggest that such disruptions may be the hidden culprit driving many tumors.