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Sage Bionetworks Coordinating Center for PS-ON and the Cancer Systems Biology Consortium (CSBC) (U24)

PS-ON Coordinating Center

Sage Bionetworks is a nonprofit biomedical research organization, founded in 2009, with a vision to promote innovations in personalized medicine by enabling a community-based approach to scientific inquiries and discoveries. It strives to activate patients and to incentivize scientists, funders, and researchers to work in fundamentally new ways in order to shape research, accelerate access to knowledge and transform human health.

Sage is located on the campus of the Fred Hutchinson Cancer Research Center in Seattle, Washington and is supported through a portfolio of philanthropic donations, competitive research grants, and commercial partnerships.


As the coordinating center for PS-ON and CSBC, Sage Bionetworks facilitates cross-project collaboration and analysis through three primary hubs:

  • Resource Hub - Serves as a clearinghouse for all data generated by the CSBC and PS-ON-funded projects. Sage has developed a software platform, Synapse, for scientists collaboratively working on biomedical research projects. This platform will house all data and methods from the programs, as well as is used as a way to make the data publicly available.
  • Outreach Hub - Works to connect PS-ON and CSBC to the greater scientific community through digital media, hosted talks, and a quarterly newsletter.
  • Collaboration and Pilot Project Hub - Focusing on actively working to get the independent centers and projects funded through PS-ON and CSBC initiatives to work together though pilot projects that combine the expertise of two or more centers. This hub capitalizes on the relationship between Sage Bionetworks and the DREAM organization to introduce large cancer-specific datasets to the community by hosting competitions to better understand the data.


Justin Guinney, Ph.D.

Justin Guinney, Ph.D.
Sage Bionetworks

Dr. Justin Guinney is Director of Computational Oncology at Sage Bionetworks and oversees Sage’s cancer research programs. He earned his Ph.D. in computational biology at Duke University in 2009 and joined Sage that same year as a research scientist.

Dr Guinney’s lab specializes in genomic data analysis for prognostic and predictive modeling of cancer outcomes and response to therapy. In support of Sage’s underlying mission to promote open systems and incentives for data sharing and collaboration, Dr Guinney has leadership roles in several “open science” initiatives including the Colorectal Cancer Subtyping Consortium, the GENIE consortium, and the DREAM Challenges consortium.

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