PS-ON Research Network

Physical Sciences – Oncology Centers (PS-OCs)

Columbia University

Principal Investigators
Drs. Raul Rabadan and Antonio Iavarone

Project Title
Topology of Cancer Evolution and Heterogeneity

Cornell University

Principal Investigators
Drs. Claudia Fischbach-Teschl and Lewis C. Cantley

Project Title
Center on the Physics of Cancer Metabolism

Dana-Farber Cancer Institute

Principal Investigators
Drs. Franziska Michor and Eric. C. Holland

Project Title
Evolution and Treatment Response of Brain, Breast, and Hematologic Malignancies

Houston Methodist Research Institute

Principal Investigators
Drs. Haifa Shen and Jenny C.N. Chang

Project Title
Center for Immunotherapeutic Transport Oncophysics

Johns Hopkins University

Principal Investigators
Drs. Denis Wirtz and Kenneth J. Pienta

Project Title
The Johns Hopkins Physical Sciences Center

Massachusetts Institute of Technology

Principal Investigators
Drs. Forest M. White and Jann N. Sarkaria

Project Title
MIT/Mayo Physical Sciences Center for Drug Distribution and Efficacy in Brain Tumors

Moffitt Cancer Center

Principal Investigators
Drs. Robert Gatenby, Alexander R.A. Anderson, and Robert J. Gillies

Project Title
Cancer as a Complex Adaptive System

Northwestern University

Principal Investigators
Drs. Thomas V. O’Halloran and Jonathan D. Licht

Project Title
Spatio-Temporal Organization of Chromatin and Information Transfer in Cancer

University of Minnesota

Principal Investigators
Drs. David J. Odde, David A. Largaespada, and Steven S. Rosenfeld

Project Title
Center for Modeling Tumor Cell Migration Mechanics

University of Pennsylvania

Principal Investigators
Dr. Dennis E. Discher

Project Title
Liver Cancer: Pre-Malignant Stiffening, Membrane Transduction, and Nuclear Rheology

Physical Sciences – Oncology Projects (PS-OPs)

City of Hope

Principal Investigators
Drs. Russell C. Rockne, Ya-Huei Kuo, and Guido Marcucci

Project Title
Information Flow and State Transitions at the System and Multi-Dimensional Scales in Leukemia Progression

Georgia Institute of Technology

Principal Investigators
Drs. Cheng Zhu and Michelle Krogsgaard

Project Title
Mechanisms of Impaired T-Cell Mechanosensing of Melanoma Antigens

Georgia Institute of Technology

Principal Investigators
Drs. Cheng Zhu and Rafi Ahmed

Project Title
Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy

Harvard University

Principal Investigators
Dr. Jeffrey Fredberg

Project Title
Epithelial Layer Jamming in Breast Cancer Cell Migration

Houston Methodist Research Institute

Principal Investigators
Drs. Kenji Yokoi, Milos Kojic, and Lidong Qin

Project Title
Biophysical Roles of Pre-Metastatic Niche Evolution on Transport of Circulating Tumor CellsBiophysical Roles of Pre-Metastatic Niche Evolution on Transport of Circulating Tumor Cells

Institute for Systems Biology

Principal Investigators
Drs. James R. Heath and Wei Wei

Project Title
Steady States and Cellular Transitions Associated with Carcinogenesis and Tumor Progression

Massachusetts General Hospital

Principal Investigators
Drs. Mehmet Toner, Daniel A. Haber, and Shyamala Maheswaran

Project Title
Metastasis and Biophysics of Clusters of Circulating Tumor Cells in the Microcirculation

Massachusetts Institute of Technology

Principal Investigators
Dr. Roger Kamm

Project Title
Quantitative Analysis of Tumor Cell Extravasation

Mayo Clinic

Principal Investigators
Drs. Kristin R. Swanson, Peter Canoll, and Leland Hu

Project Title
Image-Based Models of Tumor-Immune Dynamics in Gliobastoma

Moffitt Cancer Center

Principal Investigators
Drs. Heiko Enderling and Shari Pilon-Thomas

Project Title
Predict Radiation-Induced Shifts in Patient-Specific Immune Ecosystem Composition to Harness Immunological Consequences of Radiotherapy

Moffitt Cancer Center

Principal Investigators
Drs. Conor C. Lynch and David Basanta Gutierrez

Project Title
Defining Bone Ecosystem Effects on Metastatic Prostate Cancer Evolution and Treatment Response Using an Integrated Mathematical Modeling Approach

Texas A&M University

Principal Investigators
Dr. Tanmay P. Lele

Project Title
Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmitted by the LINC Complex

University of California, Berkeley

Principal Investigators
Drs. Jay T. Groves and Valerie M. Weaver

Project Title
ECM Geometrical and Mechanical Properties Modulate RTK Signaling

University of California, San Francisco

Principal Investigators
Drs. Zev J. Gartner, Andrei Goga, Mark A. Labarge, and Matt Thomson

Project Title
Understanding Breast Cancer Progression as a Defect in the Mechanics of Tissue Self-Organization

University of Michigan

Principal Investigators
Drs. Gary D. Luker and Joergg Lahan

Project Title
Environmental Regulation of Cancer Stem Cell Plasticity in Metastasis

University of Utah

Principal Investigators
Dr. Orly Alter

Project Title
Multi-Tensor Decompositions for Personalized Cancer Diagnostics and Prognostics

Vanderbilt University

Principal Investigators
Drs. Lisa J. McCawley, Dmitry Markov, and Katarzyna A. Rejniak

Project Title
Physical Dynamics of Cancer Response to Chemotherapy in 3D Microenvironments

Wake Forest University

Principal Investigators
Drs. Pierre Vidi and Keith D. Bonin

Project Title
Chromatin Mobility in Response to DNA Damage

PS-ON Coordinating Center

Sage Bionetworks

Principal Investigators
Dr. Justin Guinney

Project Title
Coordination Center for Open Collaboration in Systems Biology