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PS-ON Research Network

United States map showing Oncology Centers (PS-OCs) and Oncology Projects (PS-OPs).

Physical Sciences – Oncology Centers (PS-OCs)


Principal Investigators

Project Title

Columbia University

Drs. Raul Rabadan and Antonio Iavarone

Topology of Cancer Evolution and Heterogeneity

Cornell University

Drs. Claudia Fischbach-Teschl and Lewis C. Cantley

Center on the Physics of Cancer Metabolism

Dana-Farber Cancer Institute

Drs. Franziska Michor and Eric. C. Holland

Evolution and Treatment Response of Brain, Breast, and Hematologic Malignancies 

Houston Methodist Research Institute

Drs. Haifa Shen and Jenny C.N. Chang

Center for Immunotherapeutic Transport Oncophysics

Johns Hopkins University 

Drs. Denis Wirtz and Kenneth J. Pienta

The Johns Hopkins Physical Sciences Center

Massachusetts Institute of Technology

Drs. Forest M. White and Jann N. Sarkaria

MIT/Mayo Physical Sciences Center for Drug Distribution and Efficacy in Brain Tumors

Moffitt Cancer Center

Drs. Robert Gatenby, Alexander R.A. Anderson, and Robert J. Gillies 

Cancer as a Complex Adaptive System

Northwestern University

Drs. Thomas V. O’Halloran and Jonathan D. Licht

Spatio-Temporal Organization of Chromatin and Information Transfer in Cancer

University of Minnesota

Drs. David J. Odde, David A. Largaespada, and Steven S. Rosenfeld

Center for Modeling Tumor Cell Migration Mechanics

University of Pennsylvania

Dr. Dennis E. Discher

Liver Cancer: Pre-Malignant Stiffening, Membrane Transduction, and Nuclear Rheology

Physical Sciences – Oncology Projects (PS-OPs)


Principal Investigators

Project Title

City of Hope

Drs. Russell C. Rockne, Ya-Huei Kuo, and Guido Marcucci

Information Flow and State Transitions at the System and Multi-Dimensional Scales in Leukemia Progression

Georgia Institute of Technology

Drs. Cheng Zhu and Michelle Krogsgaard

Mechanisms of Impaired T-Cell Mechanosensing of Melanoma Antigens

Georgia Institute of Technology

Drs. Cheng Zhu and Rafi Ahmed 

Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy

Harvard University

Dr. Jeffrey Fredberg

Epithelial Layer Jamming in Breast Cancer Cell Migration

Houston Methodist Research Institute

Drs. Kenji Yokoi, Milos Kojic, and Lidong Qin

Biophysical Roles of Pre-Metastatic Niche Evolution on Transport of Circulating Tumor Cells

Institute for Systems Biology

Drs. James R. Heath and Wei Wei

Steady States and Cellular Transitions Associated with Carcinogenesis and Tumor Progression

Massachusetts General Hospital

Drs. Mehmet Toner, Daniel A. Haber, and Shyamala Maheswaran

Metastasis and Biophysics of Clusters of Circulating Tumor Cells in the Microcirculation

Massachusetts Institute of Technology

Dr. Roger Kamm

Quantitative Analysis of Tumor Cell Extravasation

Mayo Clinic

Drs. Kristin R. Swanson, Peter Canoll, and Leland Hu

Image-Based Models of Tumor-Immune Dynamics in Gliobastoma

Moffitt Cancer Center

Drs. Heiko Enderling and Shari Pilon-Thomas

Predict Radiation-Induced Shifts in Patient-Specific Immune Ecosystem Composition to Harness Immunological Consequences of Radiotherapy

Moffitt Cancer Center

Drs. Conor C. Lynch and David Basanta Gutierrez

Defining Bone Ecosystem Effects on Metastatic Prostate Cancer Evolution and Treatment Response Using an Integrated Mathematical Modeling Approach

Texas A&M University

Dr. Tanmay P. Lele 

Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmitted by the LINC Complex

University of California, Berkeley 

Drs. Jay T. Groves and Valerie M. Weaver

ECM Geometrical and Mechanical Properties Modulate RTK Signaling

University of California, San Francisco


Drs. Zev J. Gartner, Andrei Goga, Mark A. Labarge, and Matt Thomson

Understanding Breast Cancer Progression as a Defect in the Mechanics of Tissue Self-Organization

University of Michigan

Drs. Gary D. Luker and Joergg Lahan

Environmental Regulation of Cancer Stem Cell Plasticity in Metastasis

University of Utah

Dr. Orly Alter

Multi-Tensor Decompositions for Personalized Cancer Diagnostics and Prognostics

Vanderbilt University

Drs. Lisa J. McCawley, Dmitry Markov, and Katarzyna A. Rejniak

Physical Dynamics of Cancer Response to Chemotherapy in 3D Microenvironments

Wake Forest University

Drs. Pierre Vidi and Keith D. Bonin

Chromatin Mobility in Response to DNA Damage

PS-ON Coordinating Center


Principal Investigators

Project Title

Sage Bionetworks

Dr. Justin Guinney

Coordination Center for Open Collaboration in Systems Biology

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