PS-ON Research Network

Physical Sciences – Oncology Projects (PS-OPs)

• Biophysical Roles of Pre-Metastatic Niche Evolution on Transport of Circulating Tumor Cells

  Institution
  Houston Methodist Research Institute
  
  Principal Investigators
  Drs. Kenji Yokoi, Milos Kojic, and Lidong Qin

• Chromatin Mobility in Response to DNA Damage

  Institution
  Wake Forest University
  
  Principal Investigators
  Drs. Pierre Vidi and Keith D. Bonin

• Defining Bone Ecosystem Effects on Metastatic Prostate Cancer Evolution and Treatment Response Using an Integrated Mathematical Modeling Approach

  Institution
  Moffitt Cancer Center
  
  Principal Investigators
  Drs. Conor C. Lynch and David Basanta Gutierrez

• Environmental Regulation of Cancer Stem Cell Plasticity in Metastasis

  Institution
  University of Michigan
  
  Principal Investigators
  Drs. Gary D. Luker and Joergg Lahan

• Exploiting the Mechanobiology of PD-1 for Cancer Immunotherapy

  Institution
  Georgia Institute of Technology
  
  Principal Investigators
  Drs. Cheng Zhu and Rafi Ahmed

• Image-Based Models of Tumor-Immune Dynamics in Gliobastoma

  Institution
  Mayo Clinic
  
  Principal Investigators
  Drs. Kristin R. Swanson, Peter Canoll, and Leland Hu

• Information Flow and State Transitions at the System and Multi-Dimensional Scales in Leukemia Progression

  Institution
  City of Hope
  
  Principal Investigators
  Drs. Russell C. Rockne, Ya-Huei Kuo, and Guido Marcucci

• Mechanisms of Impaired T-Cell Mechanosensing of Melanoma Antigens

  Institution
  Georgia Institute of Technology
  
  Principal Investigators
  Drs. Cheng Zhu and Michelle Krogsgaard

• Metastasis and Biophysics of Clusters of Circulating Tumor Cells in the Microcirculation

  Institution
  Massachusetts General Hospital
  
  Principal Investigators
  Drs. Mehmet Toner, Daniel A. Haber, and Shyamala Maheswaran

• Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmitted by the LINC Complex

  Institution
  Texas A&M University
  
  Principal Investigators
  Dr. Tanmay P. Lele

• Predict Radiation-Induced Shifts in Patient-Specific Immune Ecosystem Composition to Harness Immunological Consequences of Radiotherapy

  Institution
  Moffitt Cancer Center
  
  Principal Investigators
  Drs. Heiko Enderling and Shari Pilon-Thomas

• Quantitative Analysis of Tumor Cell Extravasation

  Institution
  Massachusetts Institute of Technology
  
  Principal Investigators
  Dr. Roger Kamm

• Understanding Breast Cancer Progression as a Defect in the Mechanics of Tissue Self-Organization

  Institution
  University of California, San Francisco
  
  Principal Investigators
  Drs. Zev J. Gartner, Andrei Goga, Mark A. Labarge, and Matt Thomson