Biomimetic Tissue Engineered Systems for Advancing Cancer Research
Executive Summary
Building on great progress at the convergence of physical sciences and oncology, workshop participants envision the development of new research areas centered on harnessing biomimetic systems used in tissue engineering and regenerative medicine to advance cancer research.
Recapitulation of tumors and their context in vitro has been a challenge for cancer researchers. Notable advances have been made in cancer biology with 3D culture systems using biomimetic and natural biomaterials, microfluidic devices, and co-cultures. However, further technological developments must be achieved in order to create dynamic in vitro model systems that include multiple cellular, chemical, and physical parameters, all of which are important players in cancer biology.
The field of tissue engineering and regenerative medicine has made advances in developing in vitro and ex vivo model systems to recreate tissues and their microenvironment.
This workshop assessed the next steps for developing tissue engineered systems for cancer research and to determine what type of infrastructure or funding support may be required to advance current technologies
Agenda
7:30 a.m. - 8:00 a.m. | Security and Registration |
8:00 a.m. - 8:05 a.m. | Welcome and Opening Remarks Dinah Singer, Ph.D. National Cancer Institute |
8:05 a.m. - 8:15 a.m. | Introduction and Goals of Workshop Nastaran Kuhn, Ph.D. National Cancer Institute |
8:15 a.m. - 8:45 a.m. | Keynote Presentation: From Cancer Biomechanics to Human Organ-on-Chip Disease Models Donald Ingber, M.D., Ph.D. Wyss Institute, Harvard University |
8:45 a.m. - 10:25 a.m. | Session I: Vascularized Tissue Engineered Systems for Cancer Research Scribe: Xin Yi Chan, Ph.D., Johns Hopkins University 8:45 a.m. - 8:50 a.m. Introduction by Session Moderator 8:50 a.m. - 9:10 a.m. Vascularizing Engineered Tumor Tissue in Vitro 9:10 a.m. - 9:30 a.m. Engineering Realistic Microvessel Tumor Systems for Studying Metastasis 9:30 a.m. - 9:50 a.m. Bioengineering of Tissue Models for Cancer and Metastasis Research 9:50 a.m. - 10:25 a.m. Panel Questions and Discussion |
10:25 a.m. - 10:40 a.m. | Break |
10:40 a.m. - 12:00 p.m. | Session II: Biomimetic Systems to Probe the Cancer Physical Microenvironment Scribe: Ioannis Zervantonakis, Ph.D., Harvard University |
12:00 p.m. - 1:15 p.m. | Lunch |
12:35 p.m. - 1:15 p.m. | Poster Viewing in Terrace Room TE406
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1:15 p.m. - 1:45 p.m. | Keynote Presentation: Integrating Systems Biology and Tissue Engineering for Models of Cancer Dormancy and Drug Efficacy Linda Griffith, Ph.D. Massachusetts Institute of Technology |
1:45 p.m. - 3:45 p.m. | Session III: Correlation of Molecular Phenotypes and Tissue Function with Biomimetic Systems Scribe: Aranzazu Villasante, Ph.D., Columbia University 1:45 p.m. - 1:50 p.m. Introduction by Session Moderator 1:50 p.m. - 2:10 p.m. Tumor Engineering: Lessons from Regenerative Medicine 2:10 p.m. -2:30 p.m. Drug Sensitivity of Ewing Sarcoma Cells in 3D Biomimetic Substrates 2:30 p.m. - 2:50 p.m. Screening of Novel CRC Loci from Genome-scale Cancer Surveys in a Primary Colon Organoid System 2:50 p.m. - 3:10 p.m. Identifying Molecular Markers of Breast Epithelial Dissemination using Engineered Microenvironment Systems 3:10 p.m. - 3:45 p.m. Panel Questions and Discussion Session |
3:45 p.m. - 4:05 p.m. | Break |
4:05 p.m. - 4:45 p.m. | Breakout Discussions Moderator: Larry Nagahara, Ph.D., National Cancer Institute Scribes:
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4:45 p.m. - 5:25 p.m. | Breakout Summaries Moderator: Larry Nagahara, Ph.D., National Cancer Institute |
5:25 p.m. - 5:30 p.m. | Closing Remarks Nastaran Kuhn, Ph.D. National Cancer Institute |
Workshop Report
Summary in Cancer Research: Biomimetic Tissue–Engineered Systems for Advancing Cancer Research: NCI Strategic Workshop Report