National Cancer Institute
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FEATURED CENTER OR PROJECT

 
Vanderbilt University

Vanderbilt University PS-OP
Our project aims to develop a new computationally driven platform to examine complex physical and chemical microenvironments utilizing organ-on-chip microfluidic bioreactor technology coupled with a predictive mathematical model of tumor growth and therapeutic response. Malignant breast tumors are highly heterogeneous in terms of their cellular composition, varying levels of oxygenation, acidity, and nutrients, as well as local changes in the extracellular matrix. Furthermore, tumor tissue and tumor microenvironment properties can dynamically evolve not only during tumor growth but also when anticancer treatments are administered. Despite this, nearly all pre-clinical assessments of drug efficacy and optimal dosing are performed using homogeneous 2D cell cultures that do not resemble the cellular, metabolic, and physical features manifest in tumors in vivo. Such approach suffered from overly reductionist ex vivo/in vitro and studies may not fully recapitulate the complexity of cancers, especially their physical and chemical microenvironments.
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NETWORK

 
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Physical Science-Oncology Network

In 2015 the National Cancer Institute continued the Physical Sciences-Oncology initiative by building a collaborative network of Physical Sciences-Oncology Centers (PS-OCs) and Physical Sciences Oncology Projects (PS-OPs).

 

PHYSICAL SCIENCES-ONCOLOGY CENTERS

 
Columbia University Cancer Institute Columbia University
Physical Sciences-Oncology Center
Columbia University, New York, NY

Principal Investigators:
Raul Rabadan, Ph.D.
Antonio Iavarone, M.D.

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Cornell University Cornell University
Physical Sciences-Oncology Center
Cornell University, Ithaca, NY

Principal Investigators:
Claudia Fischbach-Teschl
Lewis C. Cantley, Ph.D.

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Dana-Farber Cancer Institute Dana-Farber Cancer Institute
Physical Sciences-Oncology Center
Dana-Farber Cancer Institute, Boston, MA

Principal Investigators:
Franziska Michor, Ph.D.
Eric C. Holland, M.D., Ph.D.

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H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Center
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigator:
Robert A. Gatenby, M.D.
Robert J. Gillies, Ph.D.
Alexander R. A. Anderson, Ph.D.

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Johns Hopkins University Johns Hopkins University
Physical Sciences-Oncology Center
Johns Hopkins University, Baltimore, MD

Principal Investigator:
Denis Wirtz, Ph.D.

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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Center
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigators:
Forest M. White, Ph.D.
Jann Sarkaria, M.D.

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The Methodist Hospital Research Institute Houston Methodist Research Institute
Physical Sciences-Oncology Center
Houston Methodist Research Institute, Houston, TX

Principal Investigator:
Mauro Ferrari, Ph.D.

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University of Minnesota University of Minnesota
Physical Sciences-Oncology Center
University of Minnesota, Minneapolis, MN

Principal Investigators:
David Odde, Ph.D.
David Largaespada, Ph.D.
Steven Rosenfeld, M.D., Ph.D.

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Northwestern University Northwestern University
Physical Sciences-Oncology Center
Northwestern University, Chicago, IL

Principal Investigators:
Thomas V. O'Halloran, Ph.D.
Jonathan D. Licht, M.D.

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University of Pennsylvania University of Pennsylvania
Physical Sciences-Oncology Center
University of Pennsylvania, Philadelphia, PA

Principal Investigator:
Dennis Discher, Ph.D.

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PHYSICAL SCIENCES-ONCOLOGY PROJECTS

 
Georgia Institute of Technology Georgia Institute of Technology
Physical Sciences-Oncology Project
Georgia Institute of Technology, Atlanta, GA

Principal Investigators:
Dr. Cheng Zhu, Ph.D.
Dr. Michelle Krogsgaard, Ph.D.
Dr. Susan Napier Thomas, Ph.D.

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Harvard University Harvard University
Physical Sciences-Oncology Project
Harvard School of Public Health, Boston, MA

Principal Investigator:
Jeffrey Fredberg, Ph.D.

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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Project
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigator:
Roger D. Kamm, Ph.D.

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University of California, Berkeley University of California, Berkeley
Physical Sciences-Oncology Project
University of California, Berkeley, Berkeley, CA

Principal Investigators:
Jay T. Groves, Ph.D.
Valerie M. Weaver, Ph.D.

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University of Michigan University of Michigan
Physical Sciences-Oncology Project
University of Michigan, Ann Arbor, MI

Principal Investigators:
Dr. Gary Luker, MD
Dr. Joerg Lahann, Ph.D.

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University of Utah University of Utah
Physical Sciences-Oncology Project
University of Utah, Salt Lake City, UT

Principal Investigator:
Orly Alter, Ph.D.

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Vanderbilt University Vanderbilt University
Physical Sciences-Oncology Project
Vanderbilt University, Nashville, TN

Principal Investigators:
Lisa J. McCawley, Ph.D.
Katarzyna Rejniak, Ph.D.
Dmitry Markov Ph.D.

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Coordinating Centers

 
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network Sage Bionetworks
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network (U24)
Seattle, WA

Principal Investigators:
Justin Guinney, Ph.D.

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