National Cancer Institute
U.S. National Institute of Health www.cancer.gov National Cancer Institute
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FEATURED CENTER OR PROJECT

 
Columbia University

Columbia University PS-OC
Recent large-scale genomic projects have begun to reveal the complex landscape of genetic alterations that cause cancer, pointing toward a powerful new paradigm for precision medicine. Despite some early successes against blood cancers, however, currently available experimental and computational methods have made limited progress in the identification of targeted therapies for solid tumors. One reason is that cells in a solid tumor are not all the same, but form many genetically distinct subpopulations of cellular clones. Recent studies have shown, for example, that gene expression signatures vary across different regions in the same tumor and that the most abundant mutations in a tumor are not always the ones that drive its growth. In addition, very small subclonal populations are often immune to the therapies that target more abundant clones, evading the effects of treatment and initiating relapse and metastasis. Such findings suggest that genomic methods that do not account for clonal heterogeneity and the dynamics of tumor development will continue to be insufficient for identifying effective targeted therapies.
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NETWORK

 
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Physical Science-Oncology Network

In 2015 the National Cancer Institute continued the Physical Sciences-Oncology initiative by building a collaborative network of Physical Sciences-Oncology Centers (PS-OCs) and Physical Sciences Oncology Projects (PS-OPs).

 

PHYSICAL SCIENCES-ONCOLOGY CENTERS

 
Columbia University Cancer Institute Columbia University
Physical Sciences-Oncology Center
Columbia University, New York, NY

Principal Investigators:
Raul Rabadan, Ph.D.
Antonio Iavarone, M.D.

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Cornell University Cornell University
Physical Sciences-Oncology Center
Cornell University, Ithaca, NY

Principal Investigators:
Claudia Fischbach-Teschl
Lewis C. Cantley, Ph.D.

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Dana-Farber Cancer Institute Dana-Farber Cancer Institute
Physical Sciences-Oncology Center
Dana-Farber Cancer Institute, Boston, MA

Principal Investigators:
Franziska Michor, Ph.D.
Eric C. Holland, M.D., Ph.D.

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H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Center
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigator:
Robert A. Gatenby, M.D.
Robert J. Gillies, Ph.D.
Alexander R. A. Anderson, Ph.D.

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Johns Hopkins University Johns Hopkins University
Physical Sciences-Oncology Center
Johns Hopkins University, Baltimore, MD

Principal Investigator:
Denis Wirtz, Ph.D.

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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Center
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigators:
Forest M. White, Ph.D.
Jann Sarkaria, M.D.

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The Methodist Hospital Research Institute Houston Methodist Research Institute
Physical Sciences-Oncology Center
Houston Methodist Research Institute, Houston, TX

Principal Investigator:
Mauro Ferrari, Ph.D.

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University of Minnesota University of Minnesota
Physical Sciences-Oncology Center
University of Minnesota, Minneapolis, MN

Principal Investigators:
David Odde, Ph.D.
David Largaespada, Ph.D.
Steven Rosenfeld, M.D., Ph.D.

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Northwestern University Northwestern University
Physical Sciences-Oncology Center
Northwestern University, Chicago, IL

Principal Investigators:
Thomas V. O'Halloran, Ph.D.
Jonathan D. Licht, M.D.

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University of Pennsylvania University of Pennsylvania
Physical Sciences-Oncology Center
University of Pennsylvania, Philadelphia, PA

Principal Investigator:
Dennis Discher, Ph.D.

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PHYSICAL SCIENCES-ONCOLOGY PROJECTS

 
Georgia Institute of Technology Georgia Institute of Technology
Physical Sciences-Oncology Project
Georgia Institute of Technology, Atlanta, GA

Principal Investigators:
Dr. Cheng Zhu, Ph.D.
Dr. Michelle Krogsgaard, Ph.D.
Dr. Susan Napier Thomas, Ph.D.

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Harvard University Harvard University
Physical Sciences-Oncology Project
Harvard School of Public Health, Boston, MA

Principal Investigator:
Jeffrey Fredberg, Ph.D.

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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Project
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigator:
Roger D. Kamm, Ph.D.

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University of California, Berkeley University of California, Berkeley
Physical Sciences-Oncology Project
University of California, Berkeley, Berkeley, CA

Principal Investigators:
Jay T. Groves, Ph.D.
Valerie M. Weaver, Ph.D.

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University of Michigan University of Michigan
Physical Sciences-Oncology Project
University of Michigan, Ann Arbor, MI

Principal Investigators:
Dr. Gary Luker, MD
Dr. Joerg Lahann, Ph.D.

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University of Utah University of Utah
Physical Sciences-Oncology Project
University of Utah, Salt Lake City, UT

Principal Investigator:
Orly Alter, Ph.D.

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Vanderbilt University Vanderbilt University
Physical Sciences-Oncology Project
Vanderbilt University, Nashville, TN

Principal Investigators:
Lisa J. McCawley, Ph.D.
Katarzyna Rejniak, Ph.D.
Dmitry Markov Ph.D.

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Coordinating Centers

 
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network Sage Bionetworks
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network (U24)
Seattle, WA

Principal Investigators:
Justin Guinney, Ph.D.

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