Dana-Farber Cancer Institute PS-OC
The principal mission of the Dana-Farber Cancer Institute Physical Sciences - Oncology Center (DFCI PS-OC) is to promote the understanding of cancer evolution and treatment responses utilizing approaches from the physical sciences intertwined with cancer biology and oncology. This center will investigate the treatment response of leukemic, brain and breast cancer cells and their microenvironment to classical and novel treatment approaches. To this end, the DFCI PS-OC will develop novel mathematical frameworks describing the evolutionary dynamics of tumor progression and treatment response that are parameterized using the experimental systems, and predict and validate optimum intervention strategies that will ultimately be implemented as prospective clinical trials. This approach will incorporate the spatio-temporal organization of evolving, heterogeneous tumor cell populations within their microenvironment. Collaborations between physical and experimental scientists in the PS-OC will bridge the chasm between the physical sciences and oncology with the ultimate goal of uncovering novel biology and enhancing patient care.