National Cancer Institute
Twitter facebook linked in Email
 

FEATURED CENTER OR PROJECT

 
University of Michigan

University of Michigan PS-OP
Emerging evidence suggests that the physical environment of tumors, including mechanical stress and physico-chemical properties of extracellular matrix, combines with genetics and cell signaling to control plasticity of cancer stem cells during metastasis, the cause of death for > 90% of patients with cancer. Metastasis encompasses processes associated with mesenchymal (invasion) and epithelial (proliferation) phenotypes. Epithelial to mesenchymal (EMT) and mesenchymal to epithelial (MET) transitions define subsets of cancer stem cells, which are implicated as critical drivers of metastasis. In particular, circulating tumor cells (CTCs) and other disseminated tumor cells commonly exhibit both epithelial and mesenchymal features, suggesting that cancer cells transition between these states. Studies of plasticity in cancer stem cells have focused predominantly on primary tumors, in part due to technological challenges of analyzing cell phenotypes and dynamics in other anatomic sites.
Learn More

NETWORK

 
network map

Physical Science-Oncology Network

In 2015 the National Cancer Institute continued the Physical Sciences-Oncology initiative by building a collaborative network of Physical Sciences-Oncology Centers (PS-OCs) and Physical Sciences Oncology Projects (PS-OPs).

Cancer TEC program (affiliated with PS-ON) Learn More

 

PHYSICAL SCIENCES-ONCOLOGY CENTERS

 
Columbia University Cancer Institute Columbia University
Physical Sciences-Oncology Center
Columbia University, New York, NY

Principal Investigators:
Raul Rabadan, Ph.D.
Antonio Iavarone, M.D.

View Now

Cornell University Cornell University
Physical Sciences-Oncology Center
Cornell University, Ithaca, NY

Principal Investigators:
Claudia Fischbach-Teschl, Ph.D.
Lewis C. Cantley, Ph.D.

View Now

Dana-Farber Cancer Institute Dana-Farber Cancer Institute
Physical Sciences-Oncology Center
Dana-Farber Cancer Institute, Boston, MA

Principal Investigators:
Franziska Michor, Ph.D.
Eric C. Holland, M.D., Ph.D.

View Now

H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Center
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigators:
Robert A. Gatenby, M.D.
Robert J. Gillies, Ph.D.
Alexander R. A. Anderson, Ph.D.

View Now

Johns Hopkins University Johns Hopkins University
Physical Sciences-Oncology Center
Johns Hopkins University, Baltimore, MD

Principal Investigator:
Denis Wirtz, Ph.D.

View Now

Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Center
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigators:
Forest M. White, Ph.D.
Jann Sarkaria, M.D.

View Now

The Methodist Hospital Research Institute Houston Methodist Research Institute
Physical Sciences-Oncology Center
Houston Methodist Research Institute, Houston, TX

Principal Investigators:
Haifa Shen, M.D., Ph.D.
Jenny C. Chang, M.D.

View Now

University of Minnesota University of Minnesota
Physical Sciences-Oncology Center
University of Minnesota, Minneapolis, MN

Principal Investigators:
David Odde, Ph.D.
David Largaespada, Ph.D.
Steven Rosenfeld, M.D., Ph.D.

View Now

Northwestern University Northwestern University
Physical Sciences-Oncology Center
Northwestern University, Chicago, IL

Principal Investigators:
Thomas V. O'Halloran, Ph.D.
Jonathan D. Licht, M.D.

View Now

University of Pennsylvania University of Pennsylvania
Physical Sciences-Oncology Center
University of Pennsylvania, Philadelphia, PA

Principal Investigator:
Dennis Discher, Ph.D.

View Now


 
 

PHYSICAL SCIENCES-ONCOLOGY PROJECTS

 
City Of Hope City of Hope
Physical Sciences-Oncology Project
City of Hope, Duarte, California

Principal Investigators:
Russell Rockne, Ph.D.
Ya-Huei Kuo, Ph.D.
Guido Marcucci, M.D.

View Now

Georgia Institute of Technology Georgia Institute of Technology
Physical Sciences-Oncology Project
Georgia Institute of Technology, Atlanta, GA

Principal Investigators:
Dr. Cheng Zhu, Ph.D.
Dr. Michelle Krogsgaard, Ph.D.
Dr. Susan Napier Thomas, Ph.D.

View Now

Georgia Institute of Technology Georgia Institute of Technology
Physical Sciences-Oncology Project
Georgia Institute of Technology, Atlanta, GA

Principal Investigators:
Dr. Cheng Zhu, Ph.D.
Dr. Rafi Ahmed, Ph.D.

View Now

H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Project
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigators:
Heiko Enderling, Ph.D.
Shari Pilon-Thomas, Ph.D.

View Now

H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Project
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigators:
Conor C. Lynch, Ph.D.
David Basanta, Ph.D.

View Now

Harvard University Harvard University
Physical Sciences-Oncology Project
Harvard School of Public Health, Boston, MA

Principal Investigator:
Jeffrey Fredberg, Ph.D.

View Now

The Methodist Hospital Research Institute Houston Methodist Research Institute
Physical Sciences-Oncology Project
Houston Methodist Research Institute, Houston, TX

Principal Investigators:
Kenji Yokoi, M.D., Ph.D.
Lidong Qin, Ph.D.,
Milos Kojic, Ph.D.
View Now

Institute of Systems Biology PS-OP Institute of Systems Biology
Physical Sciences-Oncology Project
Institute of Systems Biology, Seattle, WA

Principal Investigators:
Dr. James Heath, Ph.D.
Dr. Wei Wei, Ph.D.

View Now

Massachusetts General Hospital Massachusetts General Hospital
Physical Sciences-Oncology Project
Massachusetts General Hospital, Boston, MA

Principal Investigators:
Mehmet Toner, Ph.D.
Daniel A. Haber, M.D., Ph.D.
Shyamala Maheswaran, Ph.D.

View Now

Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Project
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigator:
Roger D. Kamm, Ph.D.

View Now

Texas A&M University Texas A&M University
Physical Sciences-Oncology Project
Texas A&M University, College Station, TX

Principal Investigators:
Tanmay P. Lele, Ph.D.

View Now

University of California, Berkeley University of California, Berkeley
Physical Sciences-Oncology Project
University of California, Berkeley, Berkeley, CA

Principal Investigators:
Jay T. Groves, Ph.D.
Valerie M. Weaver, Ph.D.

View Now

University of California San Francisco University of California, San Francisco
Physical Sciences-Oncology Project
University of Florida, Gainesville, FL

Principal Investigators:
Dr. Zev Gartner, Ph.D.
Dr. Matt Thomson, Ph.D
Dr. Mark Labarge, Ph.D
Dr. Andrei Goga, Ph.D
View Now

University of Michigan University of Michigan
Physical Sciences-Oncology Project
University of Michigan, Ann Arbor, MI

Principal Investigators:
Dr. Gary Luker, M.D.
Dr. Joerg Lahann, Ph.D.

View Now

University of Utah University of Utah
Physical Sciences-Oncology Project
University of Utah, Salt Lake City, UT

Principal Investigator:
Orly Alter, Ph.D.

View Now

Vanderbilt University Vanderbilt University
Physical Sciences-Oncology Project
Vanderbilt University, Nashville, TN

Principal Investigators:
Lisa J. McCawley, Ph.D.
Katarzyna Rejniak, Ph.D.
Dmitry Markov Ph.D.

View Now

Wake Forest University Wake Forest University
Physical Sciences-Oncology Project
Wake Forest University, Winston-Salem, North Carolina

Principal Investigators:
Pierre Vidi, Ph.D.
Keith Bonin, Ph.D.

View Now


 
 

Coordinating Centers

 
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network Sage Bionetworks
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network (U24)
Seattle, WA

Principal Investigator:
Justin Guinney, Ph.D.

View Now