National Cancer Institute
Twitter facebook linked in Email
 

FEATURED CENTER OR PROJECT

 
Georgia Tech University

Georgia Tech University PS-OP
This project investigates how the tumor microenvironment (TME) impairs in situ interactions of T-cell surface molecules with counter-molecules on the melanoma cells to suppress anti-tumor immunity. Detailed mechanistic understanding will be obtained by an integrated approach that combines physical science (PS) based tools with two complementary pre-clinical mouse models of melanoma T cell immunity, which will be further tested using bio specimens from melanoma patients. The molecular focus is the T-cell receptor (TCR) that initiates the T-cell antigen recognition upon binding to peptide-major histocompatibility complex (pMHC), and the coreceptor CD8 that co-ligates with the pMHC.
Learn More

NETWORK

 
network map

Physical Science-Oncology Network

In 2015 the National Cancer Institute continued the Physical Sciences-Oncology initiative by building a collaborative network of Physical Sciences-Oncology Centers (PS-OCs) and Physical Sciences Oncology Projects (PS-OPs).

Cancer TEC program (affiliated with PS-ON) Learn More

 

PHYSICAL SCIENCES-ONCOLOGY CENTERS

 
Columbia University Cancer Institute Columbia University
Physical Sciences-Oncology Center
Columbia University, New York, NY

Principal Investigators:
Raul Rabadan, Ph.D.
Antonio Iavarone, M.D.

View Now

Cornell University Cornell University
Physical Sciences-Oncology Center
Cornell University, Ithaca, NY

Principal Investigators:
Claudia Fischbach-Teschl
Lewis C. Cantley, Ph.D.

View Now

Dana-Farber Cancer Institute Dana-Farber Cancer Institute
Physical Sciences-Oncology Center
Dana-Farber Cancer Institute, Boston, MA

Principal Investigators:
Franziska Michor, Ph.D.
Eric C. Holland, M.D., Ph.D.

View Now

H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Center
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigators:
Robert A. Gatenby, M.D.
Robert J. Gillies, Ph.D.
Alexander R. A. Anderson, Ph.D.

View Now

Johns Hopkins University Johns Hopkins University
Physical Sciences-Oncology Center
Johns Hopkins University, Baltimore, MD

Principal Investigator:
Denis Wirtz, Ph.D.

View Now

Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Center
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigators:
Forest M. White, Ph.D.
Jann Sarkaria, M.D.

View Now

The Methodist Hospital Research Institute Houston Methodist Research Institute
Physical Sciences-Oncology Center
Houston Methodist Research Institute, Houston, TX

Principal Investigators:
Haifa Shen, M.D., Ph.D.
Jenny C. Chang, M.D.

View Now

University of Minnesota University of Minnesota
Physical Sciences-Oncology Center
University of Minnesota, Minneapolis, MN

Principal Investigators:
David Odde, Ph.D.
David Largaespada, Ph.D.
Steven Rosenfeld, M.D., Ph.D.

View Now

Northwestern University Northwestern University
Physical Sciences-Oncology Center
Northwestern University, Chicago, IL

Principal Investigators:
Thomas V. O'Halloran, Ph.D.
Jonathan D. Licht, M.D.

View Now

University of Pennsylvania University of Pennsylvania
Physical Sciences-Oncology Center
University of Pennsylvania, Philadelphia, PA

Principal Investigator:
Dennis Discher, Ph.D.

View Now


 
 

PHYSICAL SCIENCES-ONCOLOGY PROJECTS

 
Georgia Institute of Technology Georgia Institute of Technology
Physical Sciences-Oncology Project
Georgia Institute of Technology, Atlanta, GA

Principal Investigators:
Dr. Cheng Zhu, Ph.D.
Dr. Michelle Krogsgaard, Ph.D.
Dr. Susan Napier Thomas, Ph.D.

View Now

Harvard University Harvard University
Physical Sciences-Oncology Project
Harvard School of Public Health, Boston, MA

Principal Investigator:
Jeffrey Fredberg, Ph.D.

View Now

Institute of Systems Biology PS-OP Institute of Systems Biology
Physical Sciences-Oncology Project
Institute of Systems Biology, Seattle, WA

Principal Investigators:
Dr. James Heath, PhD.
Dr. Wei Wei, PhD.

View Now

Massachusetts General Hospital Massachusetts General Hospital
Physical Sciences-Oncology Project
Massachusetts General Hospital, Boston, MA

Principal Investigators:
Mehmet Toner, Ph.D.
Daniel A. Haber, MD, Ph.D.
Shyamala Maheswaran, PhD

View Now

Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Project
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigator:
Roger D. Kamm, Ph.D.

View Now

The Methodist Hospital Research Institute Houston Methodist Research Institute
Physical Sciences-Oncology Project
Houston Methodist Research Institute, Houston, TX

Principal Investigators:
Kenji Yokoi, MD, Ph.D.
Lidong Qin, Ph.D.,
Milos Kojic, Ph.D.
View Now

University of California, Berkeley University of California, Berkeley
Physical Sciences-Oncology Project
University of California, Berkeley, Berkeley, CA

Principal Investigators:
Jay T. Groves, Ph.D.
Valerie M. Weaver, Ph.D.

View Now

University of Michigan University of Michigan
Physical Sciences-Oncology Project
University of Michigan, Ann Arbor, MI

Principal Investigators:
Dr. Gary Luker, MD
Dr. Joerg Lahann, Ph.D.

View Now

University of Utah University of Utah
Physical Sciences-Oncology Project
University of Utah, Salt Lake City, UT

Principal Investigator:
Orly Alter, Ph.D.

View Now

Vanderbilt University Vanderbilt University
Physical Sciences-Oncology Project
Vanderbilt University, Nashville, TN

Principal Investigators:
Lisa J. McCawley, Ph.D.
Katarzyna Rejniak, Ph.D.
Dmitry Markov Ph.D.

View Now

Wake Forest University Wake Forest University
Physical Sciences-Oncology Project
Wake Forest University, Winston-Salem, North Carolina

Principal Investigators:
Pierre Vidi, Ph.D.
Keith Bonin, Ph.D.

View Now


 
 

Coordinating Centers

 
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network Sage Bionetworks
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network (U24)
Seattle, WA

Principal Investigator:
Justin Guinney, Ph.D.

View Now