National Cancer Institute
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FEATURED CENTER OR PROJECT

 
Harvard University

Harvard University PS-OP
If cancer cells did not migrate –and instead just stayed put– then cancer in most instances would be a more manageable disease. But cancer cells do migrate, and that migration accounts for much of cancer’s morbidity and mortality. Unfortunately, we understand little about how, why, and when this aberrant cellular migration plays out. Cancer cells tend to migrate not as individual units but rather as a cellular collective –in multicellular strings, ducts, strands and clusters. We propose that a controlling factor in that collective cellular migration is a newly discovered phenomenon called “cell jamming”. From cars streaming in highway traffic to coffee beans flowing in a chute at the supermarket to cells migrating within a living tissue, a wide variety of collective systems –both inert and living– are now known to have the capacity to jam. Within a living cell cluster, in particular, cells can jam to become quiescent, solid-like, and virtually frozen in place, or instead can unjam to become mobilized, fluid-like, and migratory. In the physiological case of healthy tissues, we do not yet know if the transition from a jammed to an unjammed state is an essential part of organogenesis, pattern formation, and wound healing. And in the pathophysiological case of malignant tissues, neither do we know if the transition from a jammed to an unjammed state is a prerequisite for invasion or metastasis.
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NETWORK

 
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Physical Science-Oncology Network

In 2015 the National Cancer Institute continued the Physical Sciences-Oncology initiative by building a collaborative network of Physical Sciences-Oncology Centers (PS-OCs) and Physical Sciences Oncology Projects (PS-OPs).

 

PHYSICAL SCIENCES-ONCOLOGY CENTERS

 
Columbia University Cancer Institute Columbia University
Physical Sciences-Oncology Center
Columbia University, New York, NY

Principal Investigators:
Raul Rabadan, Ph.D.
Antonio Iavarone, M.D.

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Cornell University Cornell University
Physical Sciences-Oncology Center
Cornell University, Ithaca, NY

Principal Investigators:
Claudia Fischbach-Teschl
Lewis C. Cantley, Ph.D.

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Dana-Farber Cancer Institute Dana-Farber Cancer Institute
Physical Sciences-Oncology Center
Dana-Farber Cancer Institute, Boston, MA

Principal Investigators:
Franziska Michor, Ph.D.
Eric C. Holland, M.D., Ph.D.

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H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Center
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigator:
Robert A. Gatenby, M.D.
Robert J. Gillies, Ph.D.
Alexander R. A. Anderson, Ph.D.

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Johns Hopkins University Johns Hopkins University
Physical Sciences-Oncology Center
Johns Hopkins University, Baltimore, MD

Principal Investigator:
Denis Wirtz, Ph.D.

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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Center
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigators:
Forest M. White, Ph.D.
Jann Sarkaria, M.D.

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The Methodist Hospital Research Institute Houston Methodist Research Institute
Physical Sciences-Oncology Center
Houston Methodist Research Institute, Houston, TX

Principal Investigator:
Mauro Ferrari, Ph.D.

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University of Minnesota University of Minnesota
Physical Sciences-Oncology Center
University of Minnesota, Minneapolis, MN

Principal Investigators:
David Odde, Ph.D.
David Largaespada, Ph.D.
Steven Rosenfeld, M.D., Ph.D.

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Northwestern University Northwestern University
Physical Sciences-Oncology Center
Northwestern University, Chicago, IL

Principal Investigators:
Thomas V. O'Halloran, Ph.D.
Jonathan D. Licht, M.D.

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University of Pennsylvania University of Pennsylvania
Physical Sciences-Oncology Center
University of Pennsylvania, Philadelphia, PA

Principal Investigator:
Dennis Discher, Ph.D.

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PHYSICAL SCIENCES-ONCOLOGY PROJECTS

 
California Institute of Technology California Institute of Technology
Physical Sciences-Oncology Project
California Institute of Technology, Pasadena, CA

Principal Investigators:
Dr. James Heath, PhD.
Dr. Wei Wei, PhD.

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Georgia Institute of Technology Georgia Institute of Technology
Physical Sciences-Oncology Project
Georgia Institute of Technology, Atlanta, GA

Principal Investigators:
Dr. Cheng Zhu, Ph.D.
Dr. Michelle Krogsgaard, Ph.D.
Dr. Susan Napier Thomas, Ph.D.

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Harvard University Harvard University
Physical Sciences-Oncology Project
Harvard School of Public Health, Boston, MA

Principal Investigator:
Jeffrey Fredberg, Ph.D.

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Massachusetts General Hospital Massachusetts General Hospital
Physical Sciences-Oncology Project
Massachusetts General Hospital, Boston, MA

Principal Investigator:
Mehmet Toner, Ph.D.
Daniel A. Haber, MD, Ph.D.
Shyamala Maheswaran, PhD

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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Project
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigator:
Roger D. Kamm, Ph.D.

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University of California, Berkeley University of California, Berkeley
Physical Sciences-Oncology Project
University of California, Berkeley, Berkeley, CA

Principal Investigators:
Jay T. Groves, Ph.D.
Valerie M. Weaver, Ph.D.

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University of Michigan University of Michigan
Physical Sciences-Oncology Project
University of Michigan, Ann Arbor, MI

Principal Investigators:
Dr. Gary Luker, MD
Dr. Joerg Lahann, Ph.D.

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University of Utah University of Utah
Physical Sciences-Oncology Project
University of Utah, Salt Lake City, UT

Principal Investigator:
Orly Alter, Ph.D.

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Vanderbilt University Vanderbilt University
Physical Sciences-Oncology Project
Vanderbilt University, Nashville, TN

Principal Investigators:
Lisa J. McCawley, Ph.D.
Katarzyna Rejniak, Ph.D.
Dmitry Markov Ph.D.

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Coordinating Centers

 
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network Sage Bionetworks
Coordinating Center for the Cancer Systems Biology Consortium and the Physical Sciences-Oncology Network (U24)
Seattle, WA

Principal Investigators:
Justin Guinney, Ph.D.

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