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Northwestern University

Northwestern University Physical Sciences Oncology Center
Northwestern University Physical Sciences-Oncology Center's (NU PS-OC) main focus is to probe the molecular basis of information flow within malignant cells. This center's studies will highlight diverse characteristics of gene expression and storage. Moreover, these investigators postulate that in the cancerous state, the epigenome is significantly mutated. By merging experimental molecular and cellular biology with the physical sciences, these investigators will examine the regulation and expression of genes. In addition, they will explore the three-dimensional organization of the genome and the higher order chromatin structure using leading-edge physical techniques. Insight into chromatin structure modifications in malignant cells has the potential to expedite the development of tools for the early diagnosis of cancer. These investigators will also provide a foundation of basic understanding for how normal gene expression is calibrated and for how the epigenome as well as the proteosome are regulated. A clear understanding of these basic molecular functions should generate novel targets for cancer therapy.
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Physical Science-Oncology Centers

The National Cancer Institute (NCI) has awarded cooperative agreements to 12 leading institutions to build a collaborative network of Physical Science-Oncology Centers (PS-OCs).



Arizona State University Arizona State University
Physical Sciences-Oncology Center
Arizona State University, Tempe, AZ

Principal Investigator: Paul Davies, Ph.D.
Scientific Investigator: William M. Grady, M.D.
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Dana-Farber Cancer Institute Dana-Farber Cancer Institute
Physical Sciences-Oncology Center
Dana-Farber Cancer Institute, Boston, MA

Principal Investigator: Franziska Michor, Ph.D.
Scientific Investigator: Eric C. Holland, M.D., Ph.D.
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Johns Hopkins University Johns Hopkins University
Physical Sciences-Oncology Center
Johns Hopkins University, Baltimore, MD

Principal Investigator: Denis Wirtz, Ph.D.
Scientific Investigator: Gregg L. Semenza, M.D., Ph.D.
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The Methodist Hospital Research Institute The Methodist Hospital Research Institute
Physical Sciences-Oncology Center
The Methodist Hospital Research Institute, Houston, TX

Principal Investigator: Mauro Ferrari, Ph.D.
Scientific Investigator: Steven A. Curley, M.D.
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Princeton University Princeton University
Physical Sciences-Oncology Center
Princeton University, Princeton, NJ

Principal Investigator: Robert H. Austin, Ph.D.
Scientific Investigator: Thea D. Tlsty, Ph.D.
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Stanford University Stanford University
Physical Sciences-Oncology Center
Stanford University, Palo Alto, CA

Principal Investigator: Jan Liphardt, Ph.D.
Scientific Investigator: Valerie M. Weaver, Ph.D.
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Cornell University Cornell University
Physical Sciences-Oncology Center
Cornell University, Ithaca, NY

Principal Investigator: Michael L. Shuler, Ph.D.
Scientific Investigator: Barbara L. Hempstead, M.D., Ph.D.
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H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Center
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigator: Robert A. Gatenby, M.D.
Scientific Investigator: Robert J. Gillies, Ph.D.
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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Center
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigator: Scott Manalis, Ph.D.
Scientific Investigator: Tyler Jacks, Ph.D.
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Northwestern University Northwestern University
Physical Sciences-Oncology Center
Northwestern University, Chicago, IL

Principal Investigator: Thomas V. O'Halloran, Ph.D.
Scientific Investigator: Jonathan D. Licht, M.D.
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The Scripps Research Institute The Scripps Research Institute
Physical Sciences-Oncology Center
The Scripps Research Institute, La Jolla, CA

Principal Investigator: Peter Kuhn, Ph.D.
Scientific Investigator: Kelly J. Bethel, M.D.
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University Of Southern California University Of Southern California
Physical Sciences-Oncology Center
University of Southern California, Los Angeles, CA

Principal Investigator: W. Daniel Hillis, Ph.D.
Scientific Investigator: David B. Agus, M.D.
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