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FEATURED CENTER

 
The Methodist Hospital Research Institute

The Methodist Hospital Research Institute
The Methodist Hospital Research Institute Physical Sciences-Oncology Center evaluates the process of mass transport in cancer to generate novel methods to improve diagnosis and treatment of cancer. This center focuses on hepatic, breast, colorectal, and pancreatic primary cancers as well on liver metastasis of the last three conditions. The investigators show that transport differentials are very important in the ability to efficiently treat malignancies. Mathematics, innovative engineered transport probes and state-of-the-art imaging are integrated to elucidate the transport physics across various physical and biological barriers related to tumorigenesis and drug delivery. Notably, this trans-disciplinary team studies the physical barriers to the evolution of liver metastasis and the administration of novel carriers to surpass these barriers. Genetic signatures which encode to mass transport variables are also being evaluated based on animal models and clinical cases. Ultimately, these studies will provide a clearer grasp of the origin, function and physics of biological barriers, and in turn will accelerate basic discovery and assist in the design for potential therapeutics.
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CENTERS

 
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Physical Science-Oncology Centers

The National Cancer Institute (NCI) has awarded cooperative agreements to 12 leading institutions to build a collaborative network of Physical Science-Oncology Centers (PS-OCs).

 

PHYSICAL SCIENCES-ONCOLOGY CENTERS

 
Arizona State University Arizona State University
Physical Sciences-Oncology Center
Arizona State University, Tempe, AZ

Principal Investigator: Paul Davies, Ph.D.
Scientific Investigator: William M. Grady, M.D.
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Dana-Farber Cancer Institute Dana-Farber Cancer Institute
Physical Sciences-Oncology Center
Dana-Farber Cancer Institute, Boston, MA

Principal Investigator: Franziska Michor, Ph.D.
Scientific Investigator: Eric C. Holland, M.D., Ph.D.
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Johns Hopkins University Johns Hopkins University
Physical Sciences-Oncology Center
Johns Hopkins University, Baltimore, MD

Principal Investigator: Denis Wirtz, Ph.D.
Scientific Investigator: Gregg L. Semenza, M.D., Ph.D.
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The Methodist Hospital Research Institute The Methodist Hospital Research Institute
Physical Sciences-Oncology Center
The Methodist Hospital Research Institute, Houston, TX

Principal Investigator: Mauro Ferrari, Ph.D.
Scientific Investigator: Steven A. Curley, M.D.
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Princeton University Princeton University
Physical Sciences-Oncology Center
Princeton University, Princeton, NJ

Principal Investigator: Robert H. Austin, Ph.D.
Scientific Investigator: Thea D. Tlsty, Ph.D.
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Stanford University Stanford University
Physical Sciences-Oncology Center
Stanford University, Palo Alto, CA

Principal Investigator: Jan Liphardt, Ph.D.
Scientific Investigator: Valerie M. Weaver, Ph.D.
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Cornell University Cornell University
Physical Sciences-Oncology Center
Cornell University, Ithaca, NY

Principal Investigator: Michael L. Shuler, Ph.D.
Scientific Investigator: Barbara L. Hempstead, M.D., Ph.D.
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H. Lee Moffitt Cancer Center & Research Institute H. Lee Moffitt Cancer Center & Research Institute
Physical Sciences-Oncology Center
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Principal Investigator: Robert A. Gatenby, M.D.
Scientific Investigator: Robert J. Gillies, Ph.D.
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Massachusetts Institute of Technology Massachusetts Institute of Technology
Physical Sciences-Oncology Center
Massachusetts Institute of Technology, Cambridge, MA

Principal Investigator: Scott Manalis, Ph.D.
Scientific Investigator: Tyler Jacks, Ph.D.
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Northwestern University Northwestern University
Physical Sciences-Oncology Center
Northwestern University, Chicago, IL

Principal Investigator: Thomas V. O'Halloran, Ph.D.
Scientific Investigator: Jonathan D. Licht, M.D.
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The Scripps Research Institute The Scripps Research Institute
Physical Sciences-Oncology Center
The Scripps Research Institute, La Jolla, CA

Principal Investigator: Peter Kuhn, Ph.D.
Scientific Investigator: Kelly J. Bethel, M.D.
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University Of Southern California University Of Southern California
Physical Sciences-Oncology Center
University of Southern California, Los Angeles, CA

Principal Investigator: W. Daniel Hillis, Ph.D.
Scientific Investigator: David B. Agus, M.D.
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