Northwestern University Physical Sciences Oncology Center
Northwestern University Physical Sciences-Oncology Center's (NU PS-OC) main focus is to probe the molecular basis of information flow within malignant cells. This center's studies will highlight diverse characteristics of gene expression and storage. Moreover, these investigators postulate that in the cancerous state, the epigenome is significantly mutated. By merging experimental molecular and cellular biology with the physical sciences, these investigators will examine the regulation and expression of genes. In addition, they will explore the three-dimensional organization of the genome and the higher order chromatin structure using leading-edge physical techniques. Insight into chromatin structure modifications in malignant cells has the potential to expedite the development of tools for the early diagnosis of cancer. These investigators will also provide a foundation of basic understanding for how normal gene expression is calibrated and for how the epigenome as well as the proteosome are regulated. A clear understanding of these basic molecular functions should generate novel targets for cancer therapy.