Dana-Farber Cancer Institute
Dana-Farber Cancer Institute Physical Sciences-Oncology Center (DFCI PS-OC) will intertwine the physical sciences with cancer biology and oncology by engaging evolutionary theory to address several critical issues concerning modern cancer research. Moreover, this center aspires to institute evolutionary modeling of cancer as a new field of study. To accomplish these goals, the center has brought together an acclaimed group of scientists from the fields of theoretical biology, cancer biology, oncology, physics and engineering. Iterative modeling will be employed to study the evolution of brain, lung, and hematopoietic tumors. Additionally, these investigators will draw on experimental data to tweak the evolutionary models that are formulated. One major evolutionary focus of this center will be to resolve which cell serves at the cell of origin for brain and hematopoietic tumors. Knowledge of the cells that initiate and drive cancer progression is critical for determining treatment options and will advance the struggle against cancer.